AustralieFrV1, Main, Exploration, bibRecord, 00AD86

Allelic loss on chromosomes 2q21 and 19p13.2 in oxyphilic thyroid tumors

Identifieur interne : 00AD86 ( Main/Exploration ); précédent : 00AD85; suivant : 00AD87

Allelic loss on chromosomes 2q21 and 19p13.2 in oxyphilic thyroid tumors

Auteurs : Karmen Stankov [Italie] ; Alessandro Pastore [Italie] ; Luca Toschi [Italie] ; James Mckay [Australie] ; Fabienne Lesueur [Royaume-Uni] ; Jean Louis Kraimps [France] ; Dominique Bonneau [France] ; Hélène Gibelin [France] ; Pierre Levillain [France] ; Marco Volante [Italie] ; Mauro Papotti [Italie] ; Giovanni Romeo [Italie]

Source :

International journal of cancer [ 0020-7136 ] ; 2004.

RBID : Pascal:04-0586379

Descripteurs français

Pascal (Inist)
- Perte hétérozygotie, Délétion, Chromosome A2 anormal, Chromosome F19 anormal, Cancérologie, Cytogénétique, Homme, Tumeur oxyphile thyroïde.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Abnormal chromosome A2, Abnormal chromosome F19, Cancerology, Cytogenetics, Deletion, Human, Loss of heterozygosity.

Abstract

Hürthle thyroid tumors are characterized by frequent numerical chromosomal aberrations, including aneuploidy or polyploidy, losses and gains of some chromosomal regions and DNA fragmentation. In recent years, great attention has been paid to the combined analysis of morphologic and genetic features of oxyphilic tumors and to the elucidation of their pathogenesis. We analyzed for loss of heterozygosity (LOH) of the candidate regions for TCO (thyroid tumor with cell oxyphilia) and NMTCI (nonmedullary thyroid carcinoma I), 2 loci already mapped on chromosomes 19p13.2 and 2q21, respectively. Matched normal and tumor DNA samples from 70 patients with sporadic oxyphilic thyroid tumors and 20 with sporadic follicular tumors were subjected to microsatellite analysis using 10 markers on 19p13.2 and 6 markers on 2q21. This approach led us to the observation of a more significant LOH in oxyphilic than in follicular tumors. Allelic loss in tumor samples was evenly distributed in both 19p13.2 and 2q21 regions, in accordance with the established linkage of TCO and NMTCI for inherited tumors. In order to investigate the possible contribution of both susceptibility loci in oxyphilic tumors, the family that led to the original mapping of TCO locus was reanalyzed for the markers in the 2q21 region. This led to the exclusion of linkage with the NMTCI locus and to the refutation of the digenic inheritance hypothesis at least in this family.

Affiliations:

Australie, France, Italie, Royaume-Uni
Nouvelle-Aquitaine, Pays de la Loire, Piémont, Poitou-Charentes
Angers, Poitiers, Turin

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Le document en format XML

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<author><name sortKey="Romeo, Giovanni" sort="Romeo, Giovanni" uniqKey="Romeo G" first="Giovanni" last="Romeo">Giovanni Romeo</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Allelic loss on chromosomes 2q21 and 19p13.2 in oxyphilic thyroid tumors</title>
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<author><name sortKey="Kraimps, Jean Louis" sort="Kraimps, Jean Louis" uniqKey="Kraimps J" first="Jean Louis" last="Kraimps">Jean Louis Kraimps</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Endocrine Surgery, Jean Bernard Hospital, Groupe de Recherche en Endocrinologie Experimentale et Clinique</s1>
<s2>Poitiers</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Poitou-Charentes</region>
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</placeName>
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<author><name sortKey="Bonneau, Dominique" sort="Bonneau, Dominique" uniqKey="Bonneau D" first="Dominique" last="Bonneau">Dominique Bonneau</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Service de Génétique Médicale, Centre Hospitalier Universitaire d'Angers</s1>
<s2>Angers</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
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<placeName><region type="region">Pays de la Loire</region>
<region type="old region">Pays de la Loire</region>
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</placeName>
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<author><name sortKey="Gibelin, Helene" sort="Gibelin, Helene" uniqKey="Gibelin H" first="Hélène" last="Gibelin">Hélène Gibelin</name>
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<s3>FRA</s3>
<sZ>6 aut.</sZ>
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<author><name sortKey="Levillain, Pierre" sort="Levillain, Pierre" uniqKey="Levillain P" first="Pierre" last="Levillain">Pierre Levillain</name>
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<sZ>6 aut.</sZ>
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<author><name sortKey="Volante, Marco" sort="Volante, Marco" uniqKey="Volante M" first="Marco" last="Volante">Marco Volante</name>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Papotti, Mauro" sort="Papotti, Mauro" uniqKey="Papotti M" first="Mauro" last="Papotti">Mauro Papotti</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Biomedical Sciences and Oncology, University of Turin</s1>
<s2>Turin</s2>
<s3>ITA</s3>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Turin</settlement>
<region type="région" nuts="2">Piémont</region>
</placeName>
</affiliation>
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<s2>Orbassano, Turin</s2>
<s3>ITA</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Turin</settlement>
<region type="région" nuts="2">Piémont</region>
</placeName>
</affiliation>
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<author><name sortKey="Romeo, Giovanni" sort="Romeo, Giovanni" uniqKey="Romeo G" first="Giovanni" last="Romeo">Giovanni Romeo</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Dipartimento di Medicina Interna, Cardioangiologia ed Epatologia, Unità Operativa di Genetica Medica, Policlinico S. Orsola-Malpighi</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
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<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">International journal of cancer</title>
<title level="j" type="abbreviated">Int. j. cancer</title>
<idno type="ISSN">0020-7136</idno>
<imprint><date when="2004">2004</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">International journal of cancer</title>
<title level="j" type="abbreviated">Int. j. cancer</title>
<idno type="ISSN">0020-7136</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Abnormal chromosome A2</term>
<term>Abnormal chromosome F19</term>
<term>Cancerology</term>
<term>Cytogenetics</term>
<term>Deletion</term>
<term>Human</term>
<term>Loss of heterozygosity</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Perte hétérozygotie</term>
<term>Délétion</term>
<term>Chromosome A2 anormal</term>
<term>Chromosome F19 anormal</term>
<term>Cancérologie</term>
<term>Cytogénétique</term>
<term>Homme</term>
<term>Tumeur oxyphile thyroïde</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Hürthle thyroid tumors are characterized by frequent numerical chromosomal aberrations, including aneuploidy or polyploidy, losses and gains of some chromosomal regions and DNA fragmentation. In recent years, great attention has been paid to the combined analysis of morphologic and genetic features of oxyphilic tumors and to the elucidation of their pathogenesis. We analyzed for loss of heterozygosity (LOH) of the candidate regions for TCO (thyroid tumor with cell oxyphilia) and NMTCI (nonmedullary thyroid carcinoma I), 2 loci already mapped on chromosomes 19p13.2 and 2q21, respectively. Matched normal and tumor DNA samples from 70 patients with sporadic oxyphilic thyroid tumors and 20 with sporadic follicular tumors were subjected to microsatellite analysis using 10 markers on 19p13.2 and 6 markers on 2q21. This approach led us to the observation of a more significant LOH in oxyphilic than in follicular tumors. Allelic loss in tumor samples was evenly distributed in both 19p13.2 and 2q21 regions, in accordance with the established linkage of TCO and NMTCI for inherited tumors. In order to investigate the possible contribution of both susceptibility loci in oxyphilic tumors, the family that led to the original mapping of TCO locus was reanalyzed for the markers in the 2q21 region. This led to the exclusion of linkage with the NMTCI locus and to the refutation of the digenic inheritance hypothesis at least in this family.</div>
</front>
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<affiliations><list><country><li>Australie</li>
<li>France</li>
<li>Italie</li>
<li>Royaume-Uni</li>
</country>
<region><li>Nouvelle-Aquitaine</li>
<li>Pays de la Loire</li>
<li>Piémont</li>
<li>Poitou-Charentes</li>
</region>
<settlement><li>Angers</li>
<li>Poitiers</li>
<li>Turin</li>
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   |wiki=    Wicri/Asie
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   |clé=     Pascal:04-0586379
   |texte=   Allelic loss on chromosomes 2q21 and 19p13.2 in oxyphilic thyroid tumors
}}

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	Serveur d'exploration sur les relations entre la France et l'Australie
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Serveur d'exploration sur les relations entre la France et l'Australie

Allelic loss on chromosomes 2q21 and 19p13.2 in oxyphilic thyroid tumors

Allelic loss on chromosomes 2q21 and 19p13.2 in oxyphilic thyroid tumors

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